(Part three of a four-part series)

Despite ongoing legal setbacks, psychedelics research has reemerged and it is proving that psilocybin reduces brain connections within the usual networks while amplifying links between less connected areas

Alterations on sustained networks seem to correlate with a reduction of depression symptoms. In the first part of 2021, two prestigious institutions began studying psilocybin therapy for depression. One compared psilocybin with traditional antidepressants (SSRI), while the other focused on psilocybin treatment for Major Depressive Disorder (MDD).

While the comparison study “did not show a significant difference in antidepressant effects between psilocybin and escitalopram,” it did bring up interesting findings and called for “larger and longer trials” comparing psilocybin with traditional antidepressants. 

Researcher Tomasso Barba has picked up the torch. His recent study found that psilocybin “is superior in reducing rumination and chronic suppression of negative emotions compared to escitalopram,” two conditions often associated with major depressive disorders.

The other 2021 trial showed positive results: nearly three-quarters of the patients in the psilocybin group reported feeling significantly better four weeks after the session, while a 50% of significant remission of other depressive symptoms …

Full story available on Benzinga.com