Tetra Bio-Pharma Inc. (OTCQB: TBPMF) (TSX:TBP) (FRA: JAM1), signed an agreement with Cellvera Global Holdings LLC, for the co-development of ARDS-003 as a combination product, with Qifenda 400mg (Favipiravir), a commercial-stage broad-spectrum antiviral drug.

As a monotherapy, compared to placebo, ARDS-003 dose-dependently reduced signs of morbidity and mortality, including respiratory distress following SARS-CoV-2 infection in the humanized ACE2 mouse model. ARDS-003 also outperformed an antiviral drug in reducing multiple proinflammatory mediators involved in hyperinflammation and immune system dysfunction following viral infection. Other studies have also demonstrated dose-dependent inhibition of viral replication.

Cellvera owns the rights to the brand originator Favipiravir, initially developed by FujiFilm Toyama Chemical Co and approved in Japan to treat pandemic influenza. Favipiravir is a selective inhibitor of viral RNA-dependent RNA polymerase with potent antiviral activity against single-stranded RNA viruses, including coronaviruses. It targets the protein needed for the coronavirus …

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