Short-acting psychedelics biotech company Small Pharma Inc. (OTCQB: DMTTF) shared positive outcomes from its Phase 2a study of SPL026, the first placebo-controlled trial of the DMT-based short-duration psychedelic compound for the treatment of Major Depressive Disorder (MDD).
The trial assessed both the efficacy and safety of a 21.5mg IV dose of SPL026 paired with supportive therapy in 34 patients with moderate to severe MDD. It was split into two phases, the first a two-week blinded, randomized, placebo-controlled trial followed by a 12-week open-label stage in which all participants received one dose of the psychedelic compound.
Analyses of secondary and exploratory endpoints like effects on self-reported depression, anxiety and wellbeing -areas often negatively impacted by depression- demonstrated that patients receiving at least one dose of the psychedelic experienced clinically relevant improvements in function and mood.
Improvements in depression scores …